Drug intelligence / Profile preview

IRT-COV

Development stage
Preclinical
Lead developer
Biological Mimetics
Modality
Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

IRT-COV is an experimental universal coronavirus vaccine candidate developed by Biological Mimetics using its proprietary Immune Refocusing Technology (IRT). The IRT platform utilizes protein engineering to mask immunodominant, highly variable epitopes on viral antigens—such as the SARS-CoV-2 spike protein—that typically act as decoys for the immune system. By dampening the response to these variable regions, the vaccine refocuses the immune system toward conserved, subdominant epitopes that are critical for viral entry and less prone to mutation. This approach is intended to elicit broad-spectrum neutralizing antibodies capable of protecting against multiple SARS-CoV-2 variants and potentially other related coronaviruses. The candidate is currently in preclinical development.

Other names
universal coronavirus vaccineIRT-COVID-19 vaccineIRT-COVID19 vaccineIRT-COVID 19 vaccine
02

Targets

SARS-CoV-2 spike

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