Drug intelligence / Profile preview

IS-003

Development stage
Preclinical
Lead developer
ImmunoScape
Modality
TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

IS-003 is an investigational T-cell receptor engineered T-cell (TCR-T) therapy currently in preclinical development by ImmunoScape. The therapy is derived from ImmunoScape's proprietary Deep Immunomics platform, which utilizes high-throughput screening of T-cell receptors from cancer patients to identify rare, high-avidity TCRs. IS-003 involves the genetic modification of a patient's T cells to express these specific TCRs, enabling the immune system to recognize and target specific antigens on tumor cells. While the specific target antigen for IS-003 has not been publicly disclosed, the program is part of a broader effort to develop next-generation cell therapies for solid tumors.

Other names
IS-003-ImmunoScape-TCR-T cell therapyIS003-ImmunoScape-TCR-T cell therapyIS 003-ImmunoScape-TCR-T cell therapy
02

Targets

MHC I (MHC class I})

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