isaridin e

Isaridin E is a **marine-derived cyclohexadepsipeptide** isolated from Beauveria felina, a fungal source[2][6]. It is a **small molecule** with potent **antiplatelet**, **antithrombotic**, and **anti-inflammatory** properties[1][2][3][4]. Pharmacologically, isaridin E inhibits ADP-induced platelet activation by selectively interfering with platelet secretion and aggregation, which are central to arterial thrombosis in cardiovascular disease. It **concentration-dependently reduces ADP-induced platelet activation** without affecting collagen- or thrombin-induced aggregation[1]. Isaridin E further reduces von Willebrand factor (vWF) secretion and blocks vWF binding to integrin αvβ3, thereby alleviating endothelial hyperpermeability and inflammation, especially relevant in sepsis models[2][5]. Its anti-inflammatory action is also mediated via suppression of the TLR4/NF-κB signaling pathway[3]. Isaridin E demonstrates a low bleeding risk compared to established agents like clopidogrel[1][4].

Other names

isaridin e