isepamicin

Isepamicin is a broad-spectrum, semisynthetic aminoglycoside antibiotic structurally related to gentamicin and amikacin. It exhibits bactericidal activity by inhibiting bacterial protein synthesis through binding to the 30S and 50S ribosomal subunits in susceptible bacteria, leading to faulty or absent proteins. Isepamicin has similar activity to amikacin but demonstrates improved efficacy against certain resistant strains, particularly those producing type I 6'-N-acetyltransferase. Its antibacterial spectrum includes Enterobacteriaceae and staphylococci; it is ineffective against anaerobes, Neisseriaceae, and streptococci. The drug displays a strong concentration-dependent bactericidal effect with a long post-antibiotic effect that allows for once-daily dosing. It is not metabolized and is excreted via the kidneys[1][5][6][7]. Primary indications include treatment of serious bacterial infections such as lower respiratory tract infections, intra-abdominal infections, urinary tract infections, skin and soft tissue infections, and septicemia[5].

Brand names

IsepacinAsepacin

Other names

isepamicine58152-03-7