ishige okamurae extract

Ishige okamurae extract is a **natural extract derived from the brown algae species Ishige okamurae**, commonly found in coastal areas of East Asia including South Korea and Japan. The extract is typically obtained through **enzyme-assisted extraction using Celluclast**, which helps break down cell walls to release bioactive compounds. The extract is particularly rich in **sulfated polysaccharides (approximately 48%)**, **fucose (approximately 44%)**, and **polysaccharides (approximately 44%)**, along with smaller amounts of proteins, phenolics, and other monosaccharides including glucose, galactose, and xylose. The extract has demonstrated multiple biological activities in preclinical studies, including **antioxidant effects** through free radical scavenging and activation of the Nrf2-Keap1 signaling pathway, **anti-inflammatory properties** by inhibiting reactive oxygen species and reducing inflammatory mediators in macrophages, **photoprotective effects** against UV-B-induced skin damage, **anti-adipogenic activity** by suppressing differentiation of preadipocytes and lipid accumulation, and potential **myogenic effects** by promoting muscle synthesis pathways. The extract has been investigated for applications in cosmeceuticals, functional foods, and potential therapeutic uses for sarcopenia and metabolic conditions. The bioactive compounds in the extract include polyphenols, fucoxanthin, diphlorethohydroxycarmalol, and ishigoside. Clinical trials are underway to evaluate its effects on muscle strength and mass in humans with low skeletal muscle mass.

Other names

IOEIshige okamurae Celluclast extractIOC