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ISIS 377131
- Development stage
- Preclinical
- Lead developer
- Ionis Pharmaceuticals
- Modality
- Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Subcutaneous
01
Overview
ISIS 377131 is a second-generation antisense oligonucleotide drug developed to target the glucocorticoid receptor (GCCR). By inhibiting the production of this receptor, ISIS 377131 aims to reduce glucocorticoid action, which in turn is expected to lower blood glucose levels, improve lipid profiles, and decrease body fat. The drug was initially developed by Ionis Pharmaceuticals (formerly Isis Pharmaceuticals) and was part of a collaboration with Ortho-McNeil (a Johnson & Johnson company) for metabolic diseases such as type 2 diabetes. The compound entered preclinical development with the goal of advancing into clinical trials for metabolic indications[4][5][7][8].
02
Targets
GR (Glucocorticoid receptor)
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