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ISIS 426115 + metformin

Development stage: Unknown
Lead developer: Ionis Pharmaceuticals
Modality: Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Molecules, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
Administration: Oral, Subcutaneous

Overview

ISIS 426115 (ISIS-GCCRRx) is an antisense oligonucleotide designed to antagonize the glucocorticoid receptor. It was investigated in combination with metformin for the treatment of type 2 diabetes mellitus. The combination aims to evaluate efficacy, safety, and tolerability versus placebo plus metformin. Metformin is a well-established oral antihyperglycemic agent that acts primarily by decreasing hepatic glucose production and improving insulin sensitivity. ISIS 426115 targets the glucocorticoid receptor at the RNA level, potentially reducing glucocorticoid-mediated insulin resistance[1][2][4][6].

Other names: ISIS-GCCRRx + metformin

Targets

ND1 (Mitochondrial electron transport chain complex I)GR (Glucocorticoid receptor)

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