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ISM0676
- Development stage
- Preclinical
- Lead developer
- InSilico Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ISM0676 is a preclinical-stage, orally bioavailable small molecule antagonist of the glucose-dependent insulinotropic polypeptide receptor (GIPR). Developed by Insilico Medicine using its generative AI platforms, Chemistry42 and Pharma.AI, the compound is designed for the treatment of obesity, type 2 diabetes, and obesity-associated cardiovascular diseases such as heart failure. Preclinical studies in humanized GIPR mice have demonstrated that ISM0676 achieves significant body weight reduction as a monotherapy and exhibits synergistic effects when co-administered with GLP-1 receptor agonists like semaglutide, while preserving lean mass. The molecule was discovered in a rapid 14-month timeframe and is characterized by high metabolic stability, low drug-drug interaction risk, and a favorable safety profile.
- Other names
- ISM0676ISM-0676ISM 0676
02
Targets
GIPR (Gastric inhibitory polypeptide receptor)
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