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Iso-DM1
- Development stage
- Unknown
- Lead developer
- ImmunoGen
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Not Applicable
01
Overview
Iso-DM1 is a control antibody-drug conjugate (ADC) used as an isotype-matched control in preclinical research studies. It consists of an isotype (non-targeting) antibody conjugated to the cytotoxic payload **DM1 (maytansinoid)** via a **SMCC linker**. The compound lacks specificity for disease-related targets but retains the cytotoxic function of DM1, serving as a critical control to compare specificity and efficacy of targeted ADCs (for example, αCD37-DM1) in cell-based and animal model experiments. Iso-DM1 is not recognized as a therapeutic or investigational agent for any human disease and is used solely for laboratory research to assess the selectivity and off-target toxicity of the DM1 payload[5].
- Brand names
- Iso-DM1Iso-DM-1Iso-DM 1
- Other names
- Iso-DM1Iso-DM-1Iso-DM 1
02
Targets
TUBB (Tubulin (alpha and beta subunits))ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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