isoalantolactone

**Isoalantolactone** is a natural sesquiterpene lactone of the eudesmanolide group, predominantly isolated from the roots of Inula helenium and other plants of the Asteraceae family[1][2]. It exhibits a broad range of pharmacological activities, including antitumor (notably proliferation inhibition, cell cycle arrest, ROS overproduction, apoptosis induction), anti-inflammatory (via NF-κB inhibition), antimicrobial, antihelminthic, antioxidant, and neuroprotective properties[1][3][5]. Mechanistically, isoalantolactone is known to induce apoptosis in cancer cells (for example, pancreatic cancer) by increasing reactive oxygen species and inhibiting the Wnt-β-catenin pathway as well as the AMPK-Skp2-Akt axis[3]. Its principal molecular pharmacodynamic actions are related to the modulation of oxidative stress and inhibition of specific intracellular signaling pathways linked to cell survival and inflammation[1][3][5].

Other names

(+)-isoalantolactoneiso-alantolactonisohelenin