isochlorogenic acid C

Isochlorogenic acid C is a naturally occurring phenolic compound classified as a dicaffeoylquinic acid derivative. It is found in various plants and foods and is produced via the condensation of quinic acid and caffeic acids. Isochlorogenic acid C exhibits multiple bioactivities including antioxidant, anti-inflammatory, antiviral (notably anti-HIV-1 integrase activity), hepatoprotective (anti-HBV), hypolipidemic (lipid-lowering), anti-fibrotic effects, and inhibition of smooth muscle contraction[9][10][6]. Mechanistically, it has been shown to: - Promote reverse cholesterol transport by upregulating LXRα-mediated pathways while downregulating LDLR and CD36 expression in macrophages. - Suppress inflammatory mediators such as iNOS, COX2, IL-1β. - Inhibit Erk/JNK/NF-κB signaling pathways to reduce inflammation-induced synovial proliferation and promote apoptosis in fibroblast-like synoviocytes[7][5]. Preclinical studies suggest potential for treating hyperlipidemia without causing liver steatosis or organ toxicity at tested doses[5]. It is primarily used for research purposes; no approved pharmaceutical formulations are available.

Other names

4,5-dicaffeoylquinic acid3,4-dicaffeoylquinic acid4,5-DCQA