isoconazole nitrate + diflucortolone valerate

Isoconazole nitrate + diflucortolone valerate is a fixed-dose combination topical medication used primarily for the initial or interim treatment of superficial fungal skin infections that are accompanied by highly inflammatory or eczematous skin conditions. Isoconazole nitrate is a broad-spectrum imidazole antifungal that acts by inhibiting ergosterol synthesis in fungal cell membranes, leading to cell death. It also exhibits antibacterial activity against some gram-positive bacteria. Diflucortolone valerate is a potent synthetic corticosteroid that reduces inflammation, pruritus, and allergic reactions in the skin by suppressing the inflammatory response and various mediators. The combination is particularly indicated where both rapid reduction of inflammation and reliable antifungal action are required, such as in tinea and other dermatomycoses affecting areas like the hands, feet (interdigital spaces), inguinal and genital regions. The product is typically formulated as a cream, with recommended short-term use to avoid complications of topical corticosteroid therapy[1][2][3][4][5][7][10].

Brand names

TravocortDuoskin

Other names

isoconazole nitrate + diflucortolone valerate