Drug intelligence / Profile preview

isoconazole nitrate + diflucortolone valerate

Development stage
Unknown
Lead developer
Vefa İlaç
Modality
Small Molecules
Administration
Topical
01

Overview

İzovef is a topical combination cream developed by Vefa İlaç, containing the antifungal agent isoconazole nitrate (1%) and the potent corticosteroid diflucortolone valerate (0.1%). It is indicated for the initial or intermediate treatment of fungal skin infections accompanied by highly inflammatory or eczematous skin conditions, such as tinea pedis, tinea corporis, and candidiasis. Isoconazole nitrate provides broad-spectrum antimicrobial activity against dermatophytes, yeasts, and molds by inhibiting fungal cell membrane synthesis. Diflucortolone valerate acts to reduce inflammation, itching, and burning associated with the infection. İzovef is a generic version of the reference drug Travocort.

Brand names
İzovef
Other names
isoconazole nitrate + diflucortolone valerate cream
02

Targets

CYP51A1 (Sterol 14α-demethylase)GR (Glucocorticoid receptor)CYP19A1 (Aromatase)CYP17A1 (Steroid 17-alpha-hydroxylase/17,20-lyase)

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