isocucurbitacin b

Isocucurbitacin B is a natural triterpenoid compound and an isomer of cucurbitacin B that has demonstrated significant antitumor activity, particularly in the context of triple-negative breast cancer (TNBC). Its primary mechanism of action involves the inhibition of the Signal Transducer and Activator of Transcription 3 (STAT3) signaling pathway. By targeting STAT3, isocucurbitacin B induces ferroptosis, a form of iron-dependent regulated cell death characterized by lipid peroxidation. Research indicates that this compound can also modulate the tumor microenvironment to enhance the efficacy of immune checkpoint inhibitors, such as anti-PD-1 antibodies, suggesting potential for combination immunotherapy strategies.