isodeoxyelephantopin

Isodeoxyelephantopin is a natural sesquiterpene lactone isolated primarily from Elephantopus scaber and Elephantopus carolinianus, plants used in traditional Asian medicine. It displays anti-cancer and anti-inflammatory effects by targeting multiple intracellular signaling pathways. Its anti-tumor activity involves the induction of apoptosis, cell cycle arrest (notably G2/M), and autophagy in cancer cells through modulation of pathways such as NF-κB, AP-1, and MAPK, and generation of reactive oxygen species (ROS). Isodeoxyelephantopin also inhibits inflammatory mediators (including inducible nitric oxide synthase, interleukins, and chemokines) in macrophages by suppressing nuclear factor-κB and activator protein-1 activity. The compound is under early preclinical investigation for its use against breast, lung, leukemia, and other cancer types, as well as inflammatory conditions[1][3][5][6][7][9][11].

Other names

sodeoxyelephantopin2-Propenoic acid, 2-methyl-, (3aR,4S,9S,11E,12aR)-2,3,3a,4,5,9,10,12a-octahydro-11-methyl-3-methylene-2,7-dioxo-7H-9,6-methenofuro[2,3-f]oxacycloundecin-4-yl ester