Drug intelligence / Profile preview

isoflavones-TNO

Development stage
Unknown
Lead developer
TNO
Modality
Small Molecules
Administration
Oral
01

Overview

isoflavones-TNO refers to a specific formulation of isoflavone-enriched foods developed and studied by TNO (Netherlands Organisation for Applied Scientific Research) for the management of postmenopausal health. These isoflavones, which are phytoestrogens typically derived from soy (such as genistein and daidzein), act as selective estrogen receptor modulators (SERMs). They are investigated for their potential to mitigate bone mineral density loss and regulate bone turnover in early postmenopausal women. By binding to estrogen receptors, these compounds aim to provide a dietary alternative to traditional hormone replacement therapy (HRT) for preventing osteoporosis and managing hormonal status during the menopausal transition.

Other names
Isoflavone-enriched foodsPhytoestrogen-rich dietsSoy isoflavones
02

Targets

ESR2 (ERβ)ESR1 (ERα)

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