isofludelone

Isofludelone is a synthetic third-generation epothilone drug discovered at Memorial Sloan Kettering Cancer Center. It functions as a tubulin inhibitor, promoting microtubule polymerization and stabilizing microtubules against depolymerization. This action disrupts normal cell division, leading to G2/M arrest and inducing apoptosis in cancer cells. Isofludelone exhibits potential anti-mitotic and antineoplastic activities. Compared to earlier epothilones, it offers increased stability, water solubility, potency, duration of action, and tumor penetration, alongside reduced toxicity. Notably, it is not a substrate for P-glycoprotein (P-gp), which helps in overcoming multidrug resistance. It is primarily indicated for the treatment of neoplasms, specifically advanced solid tumors.

Other names

iso-fludelone