Isoformononetin

Isoformononetin is a naturally occurring methoxyisoflavone, structurally related to daidzein, and classified as a hydroxyisoflavone and member of the 7-methoxyisoflavones. It is found in plants such as Glycine max (soybean) and Pueraria montana var. lobata (kudzu). Isoformononetin exhibits several biological activities, including acting as an antioxidant, anti-inflammatory agent, bone density conservation agent, apoptosis inhibitor, and immunoprotective compound. Mechanistically, it has been shown to inhibit neuroinflammation by reducing reactive oxygen species (ROS) generation and suppressing activation of the NLR family pyrin domain containing 3 (NLRP3)/ASC/IL‑1 axis in preclinical models. It also modulates apoptotic gene expression (Bax/Bcl2), inhibits Th17 and B-cell differentiation, and demonstrates neuroprotective effects against chemically induced neuronal injury in animal studies[1][3][5].

Other names

3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one4'-hydroxy-7-methoxyisoflavoneISOFORMONENTIN