isolated human pancreatic islets

Isolated human pancreatic islets (Andrew Posselt-type) refers to an experimental allogeneic cell therapy investigated by Dr. Andrew Posselt at the University of California, San Francisco (UCSF). This therapy involves the isolation of insulin-producing islets from deceased donor pancreata and their subsequent transplantation into the gastric submucosa of patients with type 1 diabetes mellitus, particularly those with hypoglycemic unawareness. Unlike the conventional method of infusing islets into the portal vein, this approach utilizes endoscopic guidance to place the islets into the intestinal or gastric submucosal space, which is hypothesized to provide a more hospitable environment for islet survival and function. The primary goal is to restore endogenous insulin production and achieve better glycemic control, potentially leading to insulin independence.

Other names

allogeneic islet transplantationgastric submucosal islet transplantationallogeneic pancreatic islet transplantation