Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
isoliensinine
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Intraperitoneal, Intravenous, Oral
01
Overview
Isoliensinine is a bisbenzylisoquinoline alkaloid extracted from the seed embryo of *Nelumbo nucifera*. It exhibits **antitumor**, **cardioprotective**, **antioxidant**, **antidepressant**, and **anti-HIV** effects, and can ameliorate type 2 diabetes with hyperlipidemia and Alzheimer's disease. It promotes autophagic death in cancer cells by activating the AMPK–TSC2–mTOR pathway and induces apoptosis in cervical and breast cancer cells. It also enhances cardiovascular protection by inhibiting coronary artery remodeling and has anti-inflammatory properties by reducing TNF-alpha and TGF-beta 1[1][2][3].
- Other names
- Lien Tze Hsin(1R)-1-[[4-hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)APEX1 (DNA-apurinic apyrimidinic site lyase)JNK (Mitogen-activated protein kinase kinase kinase family)TGFBR1RK (Ribokinase)TNFA (Tumor necrosis factor alpha (soluble))
Beyond the preview
Go deeper on isoliensinine.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on isoliensinine.