isolinderalactone

Isolinderalactone is a naturally occurring sesquiterpene lactone isolated from the root extract of *Lindera aggregata*. Preclinical publications describe it as an experimental small molecule with antineoplastic activity in cancer cell models, including colorectal cancer. In colorectal cancer cell lines, isolinderalactone has been reported to suppress proliferation and induce reactive oxygen species mediated stress responses leading to G2/M cell-cycle arrest, mitochondrial apoptosis, autophagy, and MAPK pathway activation. It does not appear to be an approved medicine or a clinically developed pharmaceutical product, and no specific commercial developer or manufacturer is clearly established from the provided evidence.

Other names

isolinderalactoneILL