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isopentyl-deoxynyboquinone
- Development stage
- Preclinical
- Lead developer
- Indiana University School of Medicine
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
IP-DNQ (isopentyl-deoxynyboquinone) is a potent, NQO1-bioactivatable quinone prodrug designed to selectively target tumors overexpressing NAD(P)H:quinone oxidoreductase 1 (NQO1). Upon enzymatic activation by NQO1, IP-DNQ undergoes futile redox cycling, leading to the rapid generation of reactive oxygen species (ROS), induction of extensive oxidative DNA damage, and depletion of cellular NAD+ and ATP. This metabolic and genomic stress triggers immunogenic cell death pathways, specifically gasdermin E (GSDME)-mediated pyroptosis. Research, particularly from Indiana University, has demonstrated that IP-DNQ synergizes with PARP inhibitors like rucaparib to amplify DNA damage and suppress tumor growth in pancreatic and lung cancer models.
- Other names
- isopentyl-deoxynyboquinone
02
Targets
NQO1
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