isoprenaline

Isoprenaline (also known as isoproterenol) is a synthetic catecholamine and non-selective beta-adrenergic agonist. It acts primarily by stimulating both β1- and β2-adrenergic receptors, leading to increased heart rate (positive chronotropy), increased cardiac contractility (positive inotropy), bronchodilation, and vasodilation. Its main clinical uses are for the treatment of acute bradycardia, heart block not caused by ventricular tachycardia or fibrillation, Adams-Stokes attacks, bronchospasm during anesthesia, cardiac arrest until more definitive therapy can be administered (such as electric shock or pacemaker), and as adjunct therapy in hypovolemic shock, septic shock, hypoperfusion states including congestive heart failure and cardiogenic shock. Isoprenaline was one of the first selective beta agonists developed in the 1940s[1][4][5]. It has a rapid onset when given intravenously with a short duration of action[6].

Brand names

Isuprel

Other names

isoproterenol3,4-Dihydroxy-α-[(isopropylamino)methyl] benzyl alcohol hydrochloride