isosorbide dinitrate

Isosorbide dinitrate is a moderate to long-acting oral organic nitrate used for the relief and prophylactic management of angina pectoris and in the treatment of heart failure. It works by relaxing blood vessels (vasodilation), which decreases the workload on the heart and increases oxygen supply to cardiac tissue. The drug acts as a prodrug that is converted to nitric oxide (NO), which activates guanylate cyclase (specifically atrial natriuretic peptide receptor 1). This leads to increased cyclic guanosine monophosphate (cGMP) levels in smooth muscle cells and results in vasodilation. It is particularly useful for preventing angina attacks when taken regularly and has also been used with hydralazine for heart failure due to systolic dysfunction[1][2][3][5][8].

Brand names

IsochronIsordil TitradoseSorbitrateDilatrate-SRIsordilIsordil TembidsBidilDilatrateIsoket

Other names

isosorbide dinitrate spray