isotonic sodium chloride solution

Isotonic sodium chloride solution, commonly known as normal saline (0.9% NaCl), is a sterile, non-pyrogenic solution of sodium chloride in water. In the context of the clinical trial conducted by Bnai Zion Medical Center for polymyalgia rheumatica (NCT04141280), it is utilized as an intramuscular placebo control. The trial evaluates the efficacy of a single micro-pulse steroid injection (betamethasone dipropionate and betamethasone sodium phosphate) as an induction therapy alongside standard oral prednisone. As a placebo, the isotonic sodium chloride solution serves as a neutral comparator to establish the baseline effect and safety profile of the experimental treatment arm, lacking active anti-inflammatory or immunomodulatory properties for the treatment of polymyalgia rheumatica.

Other names

normal saline0.9% sodium chlorideisotonic NaCl solution