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isotretinoin + cholecalciferol
- Development stage
- Phase 4
- Lead developer
- Kafrelsheikh University
- Modality
- Small Molecules
- Administration
- Inhalation, Intramuscular
01
Overview
This is an investigational combination therapy consisting of aerosolized 13-cis retinoic acid (isotretinoin) and intramuscular cholecalciferol (vitamin D), developed by Kafrelsheikh University. It is specifically designed to treat post-COVID-19 anosmia (loss of smell). The rationale is that SARS-CoV-2 binds to STRA6 receptors, leading to retinol depletion and retinoic acid insufficiency, which prevents the regeneration of olfactory sensory neurons. The treatment aims to upregulate ACE2 and STRA6 receptors and promote the regeneration of olfactory receptors and neurons. It is currently being evaluated in a Phase 4 clinical trial in Egypt.
- Other names
- 13-cis retinoic acid + vitamin Daerosolized 13-cis retinoic acid + cholecalciferolaerosolized retinoic acid + vitamin D
02
Targets
RARA (Retinoic acid receptor alpha)RARG (Retinoic acid receptor gamma)VDR (Vitamin D receptor)ACE2 (Angiotensin-converting enzyme 2)RAR (Retinoic acid receptor)STRA6 (Stimulated by retinoic acid gene 6 protein)
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