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isotretinoin + silymarin
- Development stage
- Phase 4
- Lead developer
- Tanta University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Isotretinoin + silymarin is a combination therapy being investigated by Tanta University for the treatment of moderate to severe acne vulgaris. Isotretinoin is a systemic retinoid that addresses all four major factors in acne pathogenesis: sebum production, follicular hyperkeratinization, *Cutibacterium acnes* colonization, and inflammation. Silymarin, a standardized extract from milk thistle (*Silybum marianum*), is included for its antioxidant, anti-inflammatory, and hepatoprotective properties. The combination aims to enhance therapeutic efficacy while potentially mitigating oxidative stress and inflammatory markers such as IGF-1, SAA1, and malondialdehyde (MDA) associated with acne. This regimen is currently being evaluated in a Phase 4 clinical trial to compare its efficacy against monotherapy with either agent.
- Other names
- isotretinoin and silymarin
02
Targets
RAR (Retinoic acid receptor family)RAR (Retinoic acid receptor)
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