Drug intelligence / Profile preview

iTAC-CLL01

Development stage
Unknown
Lead developer
ViferaXS
Modality
Vaccines & Immunotherapeutics, Peptides
Administration
Subcutaneous, Intradermal
01

Overview

**iTAC-CLL01** is a personalized, warehouse-based multipeptide T-cell activator being developed by ViferaXS for **chronic lymphocytic leukemia**. The product selects tumor-associated peptides from a premanufactured peptide warehouse according to an individual patient's HLA allotype and CLL immunopeptidome, with the objective of inducing anti-leukemic T-cell responses against residual disease. Public Phase I clinical reporting uses the closely corresponding name **iTAC-XS15-CLL01** and describes administration with the Toll-like receptor 1/2 ligand XS15 as an immune adjuvant during Bruton tyrosine kinase inhibitor-based treatment. The ViferaXS pipeline identifies iTAC-CLL01 as a concluded Phase I warehouse-type program.

02

Targets

Patient-specific chronic lymphocytic leukemia-associated peptide-human leukocyte antigen complexesγδ TCR (T-cell receptor)TLR1TLR2 (Toll-like Receptor 2)

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