Drug intelligence / Profile preview

Itch Guard

Development stage
Unknown
Lead developer
Reckitt
Modality
Small Molecules
Administration
Topical
01

Overview

**Itch Guard** is a topical antifungal cream primarily used to treat skin fungal infections such as ringworm, athlete's foot, jock itch, and infections in skin folds. It contains **Clotrimazole** as the active ingredient in the standard formulation, which inhibits ergosterol synthesis essential for fungal cell membrane integrity, exerting fungistatic and fungicidal effects.[1][5][8] Variants like **Itch Guard Plus** include **Terbinafine Hydrochloride**, which disrupts ergosterol production via squalene epoxidase inhibition for broader antifungal activity, often with added menthol for cooling relief from itching and irritation.[2][3][6] Manufactured by Reckitt Benckiser, it is applied topically once or twice daily to clean, dry affected areas for 1-2 weeks, providing rapid symptom relief including reduced itching, burning, and scaling.[1][3][5]

Brand names
Itch Guard
Other names
Itch Guard Cream
02

Targets

SQLE (Squalene monooxygenase)

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