ITE

**ITE** is a small-molecule, proposed endogenous ligand and agonist of the aryl hydrocarbon receptor. Chemically, it is 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester. Activation of aryl hydrocarbon receptor signaling by ITE regulates transcriptional programs involved in immune-cell differentiation, inflammation, and cellular proliferation. ITE has been investigated preclinically for immunomodulatory, anti-inflammatory, metabolic, and anticancer applications, including obesity, autoimmune disease models, and tumor models. The molecule was discovered by researchers at the University of Wisconsin–Madison and licensed for development to AhR Pharmaceuticals. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC3828045/))

Other names

2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl esterITEmethyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate