Drug intelligence / Profile preview

ITM-23

Development stage
Unknown
Lead developer
ITM Isotope Technologies Munich
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

ITM-23 is a targeted radiopharmaceutical developed by Isotope Technologies Garching (ITM) for the treatment of prostate cancer. It consists of a ligand that specifically targets the Prostate-Specific Membrane Antigen (PSMA), which is highly expressed on the surface of prostate cancer cells, including metastatic lesions. The ligand is conjugated to Terbium-161 (Tb-161), a radioisotope that emits both beta particles and a high density of Auger and conversion electrons. This dual emission profile allows for effective cell killing through DNA damage, particularly in small tumor clusters and micrometastases, while minimizing damage to adjacent healthy tissues. ITM-23 is currently in Phase 1 clinical development for patients with prostate cancer.

Other names
Tb-161-PSMATb161-PSMATb 161-PSMATerbium-161-PSMATerbium161-PSMATerbium 161-PSMA
02

Targets

PSMA (Prostate-specific membrane antigen)

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