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iTOL-200
- Development stage
- Preclinical
- Lead developer
- iTOLERANCE
- Modality
- Cell Therapies, Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Implantation
01
Overview
iTOL-200 is a 50-micron microgel developed by iTolerance, Inc. It is designed to be co-administered with a liver cell therapy to form iTOL-201. The primary goal of this therapy is to enable ectopic liver implantation without the need for chronic immunosuppression, thereby preventing graft rejection. The microgel is based on the same concept as iTOL-100 and incorporates SA-FasL microgels, suggesting a mechanism aimed at inducing immune tolerance. Early *in vitro* data indicated no significant impact on the survival of hepatocytes when co-administered with SA-FasL microgels. The next developmental step involves evaluating iTOL-201 in preclinical animal models of liver transplantation.
- Other names
- 50 micron microgel
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