itraconazole

Itraconazole is a broad-spectrum triazole antifungal agent used to treat a variety of fungal infections including aspergillosis, blastomycosis (Gilchrist’s disease), coccidioidomycosis (valley fever), histoplasmosis (Darling’s disease), paracoccidioidomycosis, sporotrichosis, and onychomycosis. It is also used for oropharyngeal and esophageal candidiasis. Itraconazole works by inhibiting the fungal cytochrome P-450-dependent enzyme lanosterol 14α-demethylase (ergosterol synthesis enzyme), leading to impaired ergosterol synthesis in the fungal cell membrane and thus inhibiting fungal growth. It can be administered orally as capsules or solution and intravenously. Itraconazole has been explored for off-label uses such as certain cancers due to its inhibition of the hedgehog signaling pathway[1][2][3][6][9].

Brand names

SporanoxTolsuraOnmel斯皮仁诺适扑诺

Other names

伊曲康唑