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ITX-5061
- Development stage
- Phase 1
- Lead developer
- iTherX Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ITX-5061 is a small molecule arylketoamide derivative that acts as an antagonist of scavenger receptor class B type 1 (SR-BI, also known as SCARB1). It was developed primarily as a hepatitis C virus (HCV) entry inhibitor, blocking the virus from entering hepatocytes by inhibiting SR-BI-mediated viral uptake. Preclinical studies demonstrated potent and selective inhibition of HCV entry across all genotypes. In clinical trials, oral administration of ITX-5061 at 150 mg/day for up to 28 days was found to be safe and well tolerated in treatment-naive HCV-infected adults; however, only limited antiviral activity was observed at the studied doses and durations. The drug reached phase I/II clinical development but further development was discontinued[1][4][5][6][7][8].
- Other names
- ITX 5061ITX5061ITX-5061
02
Targets
SCARB1 (Scavenger receptor class B member 1)
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