ivermectin + brimonidine

Ivermectin + brimonidine is a topical combination drug used in the treatment of rosacea, specifically targeting persistent erythema and inflammatory papulopustular lesions[1][2][4][5][7]. - Ivermectin is an anti-parasitic and anti-inflammatory small molecule that targets Demodex mites and inflammatory pathways, reducing papules and pustules. - Brimonidine is a selective alpha-2 adrenergic receptor agonist that causes vasoconstriction, thereby decreasing cutaneous microvascular blood flow and reducing persistent facial erythema. Combined use leverages both anti-inflammatory and vasoconstrictive mechanisms for improved efficacy compared to monotherapy, as supported by randomized controlled trials. Research supports the combination's superior effectiveness and safety profile for mild to moderate and moderate to severe rosacea[1][2][3][4][5]. The combination is available as two separate products applied simultaneously (ivermectin cream and brimonidine gel) and has also been formulated experimentally as a single topical cream[2][3].

Other names

ivermectin and brimonidine combinationivermectin 1% and brimonidine 0.33% creambrimonidine 0.33% gel and ivermectin 1% cream combination