Drug intelligence / Profile preview

ivermectin + iota-carrageenan

Development stage
Unknown
Lead developer
Merck
Modality
Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Oral, Intranasal
01

Overview

Ivermectin + iota-carrageenan is a combination therapy consisting of oral ivermectin, an antiparasitic agent with reported antiviral properties, and iota-carrageenan, a sulfated polysaccharide derived from red seaweed used as a nasal spray. This combination has been investigated primarily for the prophylaxis and early intervention of COVID-19 in high-risk populations such as healthcare workers. The proposed mechanism involves a dual barrier to viral infection: iota-carrageenan acts locally in the nasal cavity by forming a physical and possibly mucolytic barrier that impedes viral entry, while ivermectin exerts systemic antiviral effects by reducing viral replication within host cells. Clinical trials have suggested potential synergistic effects in reducing SARS-CoV-2 infection rates among exposed individuals; however, meta-analyses indicate mixed or inconclusive evidence regarding its efficacy for COVID-19 prevention or treatment[1][2][3][4][5].

Other names
IVER/IOTACRC
02

Targets

KPNA1 (Importin subunit alpha-5)Nsp9 (SARS-CoV-2 non-structural protein 9)SARS-CoV-2 spike

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