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ivonescimab + cadonilimab + etoposide + carboplatin
- Development stage
- Unknown
- Lead developer
- Akeso
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
This drug combination consists of two bispecific antibodies, ivonescimab and cadonilimab, administered alongside etoposide and carboplatin (EC) chemotherapy. Ivonescimab (AK112) is a first-in-class bispecific antibody that simultaneously targets programmed cell death protein 1 (PD-1) and vascular endothelial growth factor (VEGF). Cadonilimab (AK104) is a bispecific antibody targeting PD-1 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). This combination is being investigated in a Phase II clinical trial sponsored by Shanghai Pulmonary Hospital for the treatment of extensive-stage small cell lung cancer (ES-SCLC). The regimen aims to leverage dual checkpoint inhibition and anti-angiogenesis to enhance anti-tumor activity, while the chemotherapy components (etoposide and carboplatin) provide cytotoxic effects through topoisomerase II inhibition and DNA alkylation.
- Other names
- Ivonescimab + Cadonilimab + ECAK112 + AK104 + etoposide + carboplatinArm 1-Shanghai Pulmonary Hospital, Shanghai, China-small cell lung cancer
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)VEGFA (Vascular endothelial growth factor A)CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)TOP2A (DNA topoisomerase II)DNA
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