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IVX-A12
- Development stage
- Phase 2
- Lead developer
- AstraZeneca
- Modality
- Nanoparticles → Drug Delivery Systems, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
IVX-A12 is a bivalent, virus-like particle (VLP) vaccine candidate designed to protect against both respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). Developed by Icosavax (acquired by AstraZeneca), the vaccine utilizes computationally designed protein nanoparticle technology originating from the University of Washington. It is intended for older adults, a population at high risk for severe respiratory infections, and aims to be the first combination vaccine to address both pathogens simultaneously. The vaccine is currently Phase III-ready.
- Brand names
- IVX-A12IVX-A-12IVX-A 12
- Other names
- RSV + hMPV combination vaccineRSV/hMPV VLP vaccineinvestigational RSV and hMPV vaccine
02
Targets
RSV F (Respiratory syncytial virus fusion protein)hMPV preF (Human metapneumovirus prefusion fusion glycoprotein)
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