Drug intelligence / Profile preview

IVX-A12

Development stage
Phase 2
Lead developer
AstraZeneca
Modality
Vaccines & Immunotherapeutics, Nanoparticles → Drug Delivery Systems
Administration
Intramuscular
01

Overview

IVX-A12 is a bivalent, virus-like particle (VLP) vaccine candidate designed to protect against both respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). Developed by Icosavax (acquired by AstraZeneca), the vaccine utilizes computationally designed protein nanoparticle technology originating from the University of Washington. It is intended for older adults, a population at high risk for severe respiratory infections, and aims to be the first combination vaccine to address both pathogens simultaneously. The vaccine is currently Phase III-ready.

Brand names
IVX-A12IVX-A-12IVX-A 12
Other names
RSV + hMPV combination vaccineRSV/hMPV VLP vaccineinvestigational RSV and hMPV vaccine
02

Targets

hMPV preF (Human metapneumovirus prefusion fusion glycoprotein)RSV F (Respiratory syncytial virus fusion protein)

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