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Ivylin
- Development stage
- Unknown
- Lead developer
- Lagap
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Ivylin is an over-the-counter (OTC) herbal cough syrup containing dried ivy leaf extract (*Hedera helix*). It is used to relieve acute and chronic coughs, reduce respiratory tract inflammation, and soothe throat irritation. The active components of the extract, primarily triterpene saponins such as hederacoside C and its active metabolite alpha-hederin, exert secretolytic, mucolytic, and bronchospasmolytic effects. Alpha-hederin enhances beta-2 adrenergic receptor responsiveness by inhibiting receptor internalization, leading to bronchodilation and reduced mucus viscosity. Ivylin is marketed as a natural, non-drowsy, alcohol-free, and sugar-free formulation suitable for both adults and children.
- Brand names
- Ivylin
- Other names
- Hedera helix leaf extractivy leaf extract
02
Targets
GRK2 (G protein-coupled receptor kinase 2)ADRB2 (β2)ARRB2 (Beta-arrestin-2)
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