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IW5

Development stage: Preclinical
Lead developer: 01life Institute
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

**IW5** is an orally administered five-strain probiotic formulation, also called **Indiv Wellness**, developed as a potential microbiome-directed treatment for atopic dermatitis. It contains *Bifidobacterium lactis* UABLa-12, *Lactobacillus acidophilus* La-14, *Lactobacillus helveticus* R0052, *Lactobacillus salivarius* LS97, and *Lactobacillus casei* LC89. In an MC903-induced mouse model of atopic dermatitis, IW5 reduced dermatitis severity, inflammatory cytokine expression, mast-cell infiltration, and serum IgE. Its proposed mechanism is modulation of intestinal microbiota and increased fecal short-chain fatty acids, particularly butyrate, which promoted tolerogenic CD103-positive dendritic cells and regulatory T cells while reducing type 1 and type 2 T-cell responses. Public evidence is limited to preclinical mouse research; no human clinical efficacy has been established.

Other names: Indiv Wellness

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