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IWP-2
- Development stage
- Preclinical
- Lead developer
- UT Southwestern Medical Center
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
IWP-2 is a small molecule inhibitor of the Wnt signaling pathway. It specifically targets the enzyme Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) responsible for the palmitoylation of Wnt proteins. This post-translational modification is critical for the secretion and biological activity of Wnt ligands. By blocking Porcupine, IWP-2 prevents the activation of both canonical (β-catenin-dependent) and non-canonical Wnt signaling pathways. In research settings, it is frequently used to investigate the role of Wnt signaling in development, stem cell biology, and various cancers, including multiple myeloma, where it has been shown to reverse resistance to proteasome inhibitors like bortezomib.
- Other names
- Inhibitor of Wnt Production-2
02
Targets
PORCN (Porcupine protein)CSNK1D (Casein kinase I delta)
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