Drug intelligence / Profile preview

IX001 TCR-T cells

Development stage
Phase 1
Lead developer
Shanghai Bintie Biotechnology
Modality
TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

IX001 TCR-T cells is a T cell receptor engineered T cell therapy that targets KRAS mutations, particularly KRAS G12V. This cellular therapy involves collecting a patient's own T cells, genetically modifying them to express a T cell receptor that recognizes KRAS mutation-derived peptides presented by MHC molecules, and reinfusing them back into the patient to target and destroy cancer cells harboring these mutations. The therapy is administered intravenously and is followed by recombinant human interleukin-2 (IL-2) injection to support T cell growth and persistence.

Other names
IX001 TCR-T injectionIX-001 TCR-T injectionIX 001 TCR-T injection
02

Targets

KRAS G12V/HLA-A*11:01 (KRAS G12V Mutant Peptide-HLA-A*11:01 Complex)

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