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Drug intelligence / Profile preview
ixazomib + dexamethasone + lenalidomide + bevacizumab
- Development stage
- Preclinical
- Lead developer
- Takeda
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Oral, Intravenous
01
Overview
The "IXO regimen" refers to a combination chemotherapy protocol that includes ixazomib (a proteasome inhibitor), dexamethasone (a corticosteroid), and lenalidomide (an immunomodulatory agent). When combined with bevacizumab—a recombinant humanized monoclonal antibody targeting vascular endothelial growth factor (VEGF)—the regimen is designed for enhanced anti-tumor activity. Bevacizumab works by binding to VEGF and inhibiting angiogenesis, thereby reducing tumor vascularization and growth[3][6][8]. This combination is primarily investigated or used in the treatment of various cancers where anti-angiogenic therapy may provide benefit.
- Other names
- bevacizumab
02
Targets
CRBN (Cereblon)GR (Glucocorticoid receptor)PSMB5 (Proteasome subunit beta Type-5)VEGFA (Vascular endothelial growth factor A)
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