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ixeris sonchifolia + panax notoginseng saponins
- Development stage
- Unknown
- Lead developer
- Jilin Aodong Pharmaceutical Group
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Sublingual, Intravenous, Intramuscular, Subcutaneous
01
Overview
A combination of botanical extracts derived from *Ixeris sonchifolia* (known as Kudiezi in Traditional Chinese Medicine) and *Panax notoginseng* saponins (PNS, often marketed as Xueshuantong). This combination is widely used in China, particularly in intravenous form, for the treatment of cardiovascular and cerebrovascular diseases, including coronary heart disease, angina pectoris, and ischemic stroke. *Ixeris sonchifolia* contributes flavonoids and adenosine, which exhibit anti-inflammatory and anti-platelet properties, while *Panax notoginseng* saponins provide ginsenosides that enhance microcirculation, inhibit platelet aggregation, and offer neuroprotection. Together, they act synergistically to improve blood flow, reduce blood viscosity, and protect tissues from ischemia-reperfusion injury.
- Brand names
- KudieziXueshuantongXueshuanningZhenyuan
- Other names
- Kudiezi and Xueshuantong combinationIxeris sonchifolia and Panax notoginseng saponinsKudiezi + XueshuantongIxeridium sonchifolium + Panax notoginseng saponinsPNS
02
Targets
AKR1C3 (Aldo-keto reductase family 1 member C3)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)EGFR (Epidermal growth factor receptor)P2Y12 (Purinergic P2Y12 receptor)ADOR (Adenosine receptors)PGHS-1 (Prostaglandin G/H Synthase 1)NOS1 (nNOS)CaV (Voltage-gated calcium channel protein complex)
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