Drug intelligence / Profile preview

ixeris sonchifolia + panax notoginseng saponins

Development stage: Unknown
Lead developer: Jilin Aodong Pharmaceutical Group
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral, Sublingual, Intravenous, Intramuscular, Subcutaneous

Overview

A combination of botanical extracts derived from *Ixeris sonchifolia* (known as Kudiezi in Traditional Chinese Medicine) and *Panax notoginseng* saponins (PNS, often marketed as Xueshuantong). This combination is widely used in China, particularly in intravenous form, for the treatment of cardiovascular and cerebrovascular diseases, including coronary heart disease, angina pectoris, and ischemic stroke. *Ixeris sonchifolia* contributes flavonoids and adenosine, which exhibit anti-inflammatory and anti-platelet properties, while *Panax notoginseng* saponins provide ginsenosides that enhance microcirculation, inhibit platelet aggregation, and offer neuroprotection. Together, they act synergistically to improve blood flow, reduce blood viscosity, and protect tissues from ischemia-reperfusion injury.

Brand names: KudieziXueshuantongXueshuanningZhenyuan
Other names: Kudiezi and Xueshuantong combinationIxeris sonchifolia and Panax notoginseng saponinsKudiezi + XueshuantongIxeridium sonchifolium + Panax notoginseng saponinsPNS

Targets

AKR1C3 (Aldo-keto reductase family 1 member C3)EGFR T790M (Epidermal growth factor receptor T790M mutant)P2Y12 (Purinergic P2Y12 receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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