Ixprim

Ixprim is a fixed-dose combination analgesic consisting of tramadol hydrochloride and paracetamol (acetaminophen). Tramadol is a centrally acting synthetic opioid analgesic that functions as a mu-opioid receptor agonist and a weak inhibitor of the neuronal reuptake of norepinephrine and serotonin. Paracetamol is a non-opioid analgesic and antipyretic whose mechanism likely involves the inhibition of prostaglandin synthesis in the central nervous system. This combination is indicated for the management of moderate to severe pain, providing a synergistic effect that allows for lower doses of each component compared to monotherapy. In a Phase 4 clinical trial (NCT01782846) conducted by Hopital Foch, Ixprim was evaluated for its analgesic efficacy in emergency department patients presenting with moderate pain, specifically comparing its performance against a codeine/paracetamol combination (Dafalgan-Codeine).

Brand names

Ixprim

Other names

tramadol + paracetamoltramadol + acetaminophentramadol hydrochloride + paracetamol