J591 minibody

The J591 minibody is an engineered antibody fragment designed to target the extracellular domain of Prostate Specific Membrane Antigen (PSMA). It is a homodimer consisting of two single-chain variable fragments (scFv) derived from the deimmunized huJ591 monoclonal antibody, each linked to a human IgG1 CH3 domain via an artificial hinge sequence. This format is optimized for pharmacokinetics, providing rapid tumor localization and faster blood clearance compared to full-length antibodies, which enhances its utility as an imaging agent for positron emission tomography (PET) and single-photon emission computed tomography (SPECT). When conjugated with chelators like DOTA and labeled with radionuclides such as Copper-64, Iodine-124, or Indium-111, it serves as a high-contrast diagnostic tool for staging and monitoring prostate cancer and other solid tumors characterized by PSMA-expressing neovasculature. It also holds potential for radioimmunotherapy when labeled with beta-emitting isotopes like Yttrium-90.

Other names

huJ591 minibodyhuJ-591 minibodyhuJ 591 minibodyanti-PSMA minibodyJ591-DOTA minibodyJ-591-DOTA minibodyJ 591-DOTA minibody124I-J591 minibody64Cu-DOTA-J591 minibody