Drug intelligence / Profile preview

jabuticaba leaf intestinal digested fraction

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Jabuticaba leaf intestinal digested fraction is a bioactive extract derived from the leaves of *Myrciaria cauliflora* that has undergone simulated gastrointestinal digestion. This specific fraction is characterized by a distinct phenolic profile, notably containing 3,4-dihydroxybenzoic acid and ferulic acid, which are released or formed during the digestion process. Research indicates that this fraction possesses significant antiproliferative and cytotoxic properties against hepatocellular carcinoma (HepG2) cells. Its mechanism of action involves the induction of both apoptotic and necrotic cell death, inhibition of cell migration, and potent antioxidant activity through the reduction of reactive oxygen species (ROS) generation. It is being bioprospected for potential applications as a nutraceutical or functional food component in the context of cancer prevention and management.

Other names
Myrciaria cauliflora leaf intestinal digested fractiondigested jabuticaba leaf extract

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