Drug intelligence / Profile preview

jaceidin

Development stage
Preclinical
Modality
Small Molecules
01

Overview

Jaceidin is a methoxylated flavonoid naturally occurring in various plant species, including *Varthemia iphionoides* and members of the *Centaurea* genus. It is currently being investigated as a potential lead compound for the treatment of metastatic prostate cancer. Research indicates that jaceidin exhibits cytotoxic activity against cancer cell lines, such as PC3 and DU145, by inducing apoptosis through the depolarization of the mitochondrial membrane and the modulation of cell-cycle dynamics. In silico ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling suggests that jaceidin possesses favorable drug-likeness properties, making it a candidate for further pharmaceutical development as a scaffold for novel antineoplastic therapies.

Other names
5,7,4'-trihydroxy-3,6,3'-trimethoxyflavone3,6,3'-trimethoxyquercetin3',5,7-trihydroxy-3,4',6-trimethoxyflavone

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