JAGGED2 shRNA

JAGGED2 shRNA is a short hairpin RNA (shRNA) therapeutic candidate designed to silence the expression of the JAGGED2 gene, a ligand for the Notch signaling pathway. In multiple myeloma, JAGGED2 is often overexpressed and contributes to the spontaneous clonogenicity, survival, and proliferation of malignant plasma cells. By delivering the shRNA via a lentiviral system, researchers can achieve stable down-regulation of JAGGED2, which leads to the inhibition of Notch signaling, resulting in reduced cell growth and the induction of apoptosis. This agent is primarily utilized in preclinical research to validate JAGGED2 as a therapeutic target in hematological malignancies.

Other names

JAG2 shRNAJAG-2 shRNAJAG 2 shRNAshRNA targeting JAGGED2