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Jagiellonian Univ. Medical College SIRT2 compound 3
- Development stage
- Unknown
- Lead developer
- Jagiellonian University Medical College
- Modality
- Small Molecules
01
Overview
Jagiellonian Univ. Medical College SIRT2 compound 3: sourced facts only. name: "Biochemical studies revealed their SIRT2 inhibitory activity ranging from 48.5 % (compound 4, 5-chloro-2-((4-(3-methoxyphenyl)piperazin-1-yl)methyl)-9H-xanthen-9-one hydrochloride) to 93.2 % (compound 3, 5-chloro-2-(((2-methoxyphenethyl)amino)methyl)-9H-xanthen-9-one hydrochloride)." [PMID:38280655]; target: "Biochemical studies revealed their SIRT2 inhibitory activity ranging from 48.5 % (compound 4, 5-chloro-2-((4-(3-methoxyphenyl)piperazin-1-yl)methyl)-9H-xanthen-9-one hydrochloride) to 93.2 % (compound 3, 5-chloro-2-(((2-methoxyphenethyl)amino)methyl)-9H-xanthen-9-one hydrochloride)." [PMID:38280655]; developer: "Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland." [PMID:38280655]; modality: "Six amino derivatives of xanthone were obtained via chemical synthesis." [PMID:38280655]
02
Targets
SIRT2 (NAD-dependent protein deacetylase sirtuin-2)
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